Newer insights into the aetiology and pathogenesis of myeloperoxidase associated autoimmunity.

Newer Insights into the Prsevention of the Common Cold

Since most colds are self-limiting, symptoms will usually resolve on their own in seven to ten days. For the majority of patients, treatment is symptomatic and targeted at the most bothersome symptoms. Specific nonprescription therapy may relieve cold symptoms but should be used with caution, especially in at-risk patient populations. Patients should monitor for worsening symptoms, and progress...

Insights into the autistic disorder and potential therapeutic approaches

Autism and autism spectrum disorders (ASDs) such as Rett syndrome and Asperger syndromeare enigmatic and complex neurodevelopmental disorders, thought to have originated inparticular interactions of genetic and environmental factors. Despite the extensive research,exact mechanism of pathogenesis is not still completely understood. ASDs are characterizedby deficits and abnormalities in communica...

Unravelling the Pathogenesis of Severe COVID-19 Pneumonia: Are There Possible Insights From High Altitude?

Diagnosis and treatment of systemic and localized scleroderma

Department of Clinical Immunology and Rheumatology, Sahara Hospital, Lucknow, India, 226010 [email protected] Scleroderma or progressive systemic sclerosis is diagnosed clinically by typical features of skin thickening, Raynaud’s phenomenon and visceral organ involvement, and serologically by distinct autoantibody subsets. These differentiate the disease into the ‘limited’ and ‘diffuse’ vari...

The C3aR promotes macrophage infiltration and regulates ANCA production but does not affect glomerular injury in experimental anti-myeloperoxidase glomerulonephritis

The anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitides are autoimmune diseases associated with significant morbidity and mortality. They often affect the kidney causing rapidly progressive glomerulonephritis. While signalling by complement anaphylatoxin C5a though the C5a receptor is important in this disease, the role of the anaphylatoxin C3a signalling via the C3a receptor (C...